Our technology
Revolutionizing diagnostics with our breakthrough technology: We've seamlessly integrated magnetic hyperthermia and electrochemical detection within a microfluidic chip. With two patents, registered know-how, and a wealth of scientific publications, we offer the future of precision, affordability, speed, and multiplexing capabilities in diagnostics—setting us apart from conventional methods like RT-PCR.
Magnetic hyperthermia
By leveraging the power of magnetic nanoparticles, our technology achieves what was once thought impossible. We capture elusive miRNAs even within complex samples, providing unparalleled specificity and sensitivity. Then, employing hyperthermia, we effortlessly release these miRNAs, unlocking a new realm of possibilities for precise diagnostics and early disease detection
Microfluidic integration
Microfluidic technologies are at the heart of our innovation, enabling a transformative shift in diagnostics. With their precision and miniaturization, we drastically reduce the required sample volume, expand the scope of analyzed miRNAs, slash analysis time, minimize costs, and heighten sensitivity. This empowers us to provide faster, more comprehensive, and cost-effective diagnostic solutions that set new industry standards
Electrochemical detection
The incorporation of electrochemical detection into our system represents a groundbreaking advancement. This integration significantly lowers the limit of detection, making it possible to identify even trace amounts of miRNAs with exceptional accuracy. What's more, it simplifies the readout process, allowing for the use of straightforward electronic systems. This innovation not only enhances the precision of our technology but also streamlines its practical application, making it accessible and efficient for a wide range of users
Scientific publications
M C Horny, M Lazerges J M Siaugue A Pallandre A M Haghiri Gosnet J Gamby DNA electrochemical hybridization detection in droplets using gold ultramicroelectrodes in a two electrode
configuration ECS Trans 72 31 2016 1 6
M ..−C Horny, M Lazerges J ..−M Siaugue A Pallandre D Rose, F Bedioui C Deslouis A ..−M Haghiri−Gosnet J Gamby Electrochemical DNA biosensors based on long−range electron transfer
investigating the efficiency of a fluidic channel microelectrode compared to an ultramicroelectrode in a two−electrode setup Lab Chip 2016 16 4373 4381
Q Zhang, M Zhang, L Djeghlaf J Bataille, J Gamby A M Haghiri Gosnet A Pallandre § Logic digital fluidic in miniaturized functional devices Perspective to the next generation of microfluidic lab
on chips Electrophoresis, 2017 38 7 1 24
M C Horny, V Dupuis, J M Siaugue and J Gamby Release and detection of microRNA by combining magnetic hyperthermia and electrochemistry modules on a microfluidic Sensor 2021 21 1 185
1 18
M C Horny, J Gamby V Dupuis, and J M Siaugue and Magnetic hyperthermia on γ Fe 2 O 3 @SiO 2 core shell nanoparticles for mi RNA 122 detection Nanomaterials 2021 11 1 149 1 25
M. C. Horny, F. Billon, A. Pailleret , C. Deslouis , V. Dupuis, M. lazerges , M. Siaugue , and J. Gamby . Amorphous carbon nitride microband integrated in a microfluidic device for DNA biosensors
applications. J. Electroanal . Chem ., 2021 , 895 , 115395, 1 7.
P Gonzalez Losada, M Freisa C Poujouly and J Gamby An integrated multiple electrochemical miRNA sensing system embedded into a microfluidic Chip Biosensors 2022 12 45
C Poujouly P Gonzalez Losada, R Boukraa M Freisa J Le Gall, D Bouville C Deslouis and J Gamby Diffusion convection impedance for a micro band electrode under microfluidic conditions
Electrochemistry Comm 2022 137 107262
C Poujouly J Le Gall, M Freisa D Kechkeche D Bouville J Khemir P Gonzalez Losada, and J Gamby Microfluidic chip for the electrochemical detection of microRNAs methylene blue increasing
the specificity Frontiers in Chemistry 2022 10 868909
Patents
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Patent : FR 3072097 2017 10 05 Method for detecting nucleic acid molecules by magnetic hyperthermia and kit therefor
Protected in France and USA
Patent: FR 2112764 2021 11 30 Binding of nucleic acids on platinum electrodes
Protected in France and PCT application 052201 (ongoing since 2022 11 30